Title : Structure-activity relationships of gastrointestinal hormones: motilin, GIP, and [27-TYR]CCK-PZ.

Pub. Date : 1977 Apr

PMID : 190081






1 Functional Relationships(s)
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1 In a series of motilin peptides, elimination of the pentapeptide from the amino terminus decreased the activity (in vitro contraction of rabbit duodenal muscle) to 1/250 of the whole molecule, and subsequent removal of the tripeptide Thr-Tyr-Gly resulted in the complete loss of its effects, In a series of gastric inhibitory peptides, two fragments corresponding to positions 1 to 28 and 26 to 43 were both inactive. Thr-Tyr-Gly promotilin Oryctolagus cuniculus