Title : Calcium-channel blockers reduce the antiplatelet effect of clopidogrel.

Pub. Date : 2008 Nov 4

PMID : 19007592






2 Functional Relationships(s)
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1 OBJECTIVES: Because of the known CYP3A4 inhibition by calcium-channel blockers (CCBs), we hypothesized that there might be a drug-drug interaction between clopidogrel and dihydropyridines in patients with coronary artery disease. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 BACKGROUND: Clopidogrel is activated by CYP3A4, which also metabolizes CCBs of the dihydropyridine class. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens