Pub. Date : 2008 Nov 15
PMID : 19005408
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen peroxide-induced VCAM-1 expression in pancreatic islets and beta-cells through extracellular Ca2+ influx. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 2 | The role of Ca2+ in H2O2-induced VCAM-1 expression was investigated in beta-cell lines using an extracellular Ca2+ chelator and Ca2+-depleted media. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 3 | Furthermore, H2O2-induced VCAM-1 expression was measured in beta-cells, pretreated with inhibitors of protein kinase C, phospholipase D, and phosphatidylinositol-3 kinase/Akt. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 4 | Finally, H2O2-induced VCAM-1 expression was evaluated in porcine islets and rodent beta-cell lines infected with an adenovirus encoding catalase, a H2O2-removing enzyme. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 5 | Finally, H2O2-induced VCAM-1 expression was evaluated in porcine islets and rodent beta-cell lines infected with an adenovirus encoding catalase, a H2O2-removing enzyme. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 6 | RESULTS: H2O2 was most potent inflammatory stimulator of VCAM-1 expression in porcine islets and had the greatest effect on VCAM-1 expression by beta-cells. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 7 | RESULTS: H2O2 was most potent inflammatory stimulator of VCAM-1 expression in porcine islets and had the greatest effect on VCAM-1 expression by beta-cells. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 8 | Signaling pathway analysis demonstrated that extracellular Ca2+ influx was critical to H2O2-mediated VCAM-1 expression; however, protein kinase C, phospholipase D, and phosphatidylinositol-3 kinase/Akt activation were not required for VCAM-1 expression. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 9 | Signaling pathway analysis demonstrated that extracellular Ca2+ influx was critical to H2O2-mediated VCAM-1 expression; however, protein kinase C, phospholipase D, and phosphatidylinositol-3 kinase/Akt activation were not required for VCAM-1 expression. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 10 | Finally, catalase overexpression inhibited H2O2-induced VCAM-1 expression by islets and beta-cell lines. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |
| 11 | CONCLUSION: An extracellular calcium-dependent H2O2 pathway is the critical mediator of VCAM-1 expression by pancreatic islets and beta-cells. | Hydrogen Peroxide | vascular cell adhesion molecule 1 | Homo sapiens |