Title : Induction of alkoxyresorufin O-dealkylases and UDP-glucuronosyl transferase by phenobarbital and 3-methylcholanthrene in primary cultures of porcine ciliary epithelial cells.

Pub. Date : 1991 Feb 15

PMID : 1900006






4 Functional Relationships(s)
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1 Induction of alkoxyresorufin O-dealkylases and UDP-glucuronosyl transferase by phenobarbital and 3-methylcholanthrene in primary cultures of porcine ciliary epithelial cells. Phenobarbital UDP glucuronosyltransferase family 1 member A1 Homo sapiens
2 UDP-GT activity increased about 5-fold in PB-treated PE cells and about 4-fold in PB-treated NPE cells in 48 hr. Phenobarbital UDP glucuronosyltransferase family 1 member A1 Homo sapiens
3 UDP-GT activity increased about 5-fold in PB-treated PE cells and about 4-fold in PB-treated NPE cells in 48 hr. Phenobarbital UDP glucuronosyltransferase family 1 member A1 Homo sapiens
4 Induction by PB and MC of ER O-dealkylase, PR O-dealkylase and UDP-GT activities in ciliary NPE and PE cells was inhibited almost completely by 3.5 microM cyclohexamide and 40 nM actinomycin D. Phenobarbital UDP glucuronosyltransferase family 1 member A1 Homo sapiens