Title : Stoichiometric interaction of smg p21 with its GDP/GTP exchange protein and its novel action to regulate the translocation of smg p21 between membrane and cytoplasm.

Pub. Date : 1991 Feb 14

PMID : 1900001






10 Functional Relationships(s)
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Protein Name
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1 Stoichiometric interaction of smg p21 with its GDP/GTP exchange protein and its novel action to regulate the translocation of smg p21 between membrane and cytoplasm. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 Stoichiometric interaction of smg p21 with its GDP/GTP exchange protein and its novel action to regulate the translocation of smg p21 between membrane and cytoplasm. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
3 We have previously purified a GDP/GTP exchange protein for smg p21A and -B, members of a ras p21/ras p21-like small GTP-binding protein superfamily. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
4 We have previously purified a GDP/GTP exchange protein for smg p21A and -B, members of a ras p21/ras p21-like small GTP-binding protein superfamily. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
5 We have previously purified a GDP/GTP exchange protein for smg p21A and -B, members of a ras p21/ras p21-like small GTP-binding protein superfamily. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
6 We have previously purified a GDP/GTP exchange protein for smg p21A and -B, members of a ras p21/ras p21-like small GTP-binding protein superfamily. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
7 This regulatory protein, named smg p21 GDP dissociation stimulator (GDS), stimulates the dissociation of both GDP and GTP from and the subsequent binding of both GDP and GTP to smg p21s. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
8 This regulatory protein, named smg p21 GDP dissociation stimulator (GDS), stimulates the dissociation of both GDP and GTP from and the subsequent binding of both GDP and GTP to smg p21s. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
9 We show here that smg p21 GDS forms a complex with both the GDP- and GTP-bound forms of smg p21B at a molar ratio of about 1:1. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
10 These results indicate that smg p21 GDS stoichiometrically interacts with smg p21B and thereby regulates its GDP/GTP exchange reaction and its translocation between membranes and cytoplasm. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens