Title : Docosahexaenoic acid induces ERK1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma SH-SY5Y cells.

Pub. Date : 2009 Jan

PMID : 18996496






2 Functional Relationships(s)
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1 From immunoblotting experiments, we observed that DHA induced the ROS production, protein tyrosine phosphatase inhibition, mitogen-activated protein kinase (MAPK)/ERK kinase (MEK) phosphorylation, and sequentially ERK1/2 phosphorylation, the last of which was significantly reduced by MEK inhibitor U0126. dehydroacetic acid mitogen-activated protein kinase 1 Homo sapiens
2 These results suggest that the ROS-dependent ERK pathway, rather than PI3K, plays an important role during DHA-enhanced neurite outgrowth. dehydroacetic acid mitogen-activated protein kinase 1 Homo sapiens