Title : Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.

Pub. Date : 2008 Dec 15

PMID : 18992797






2 Functional Relationships(s)
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1 Cells co-expressing either hCYP1B1 or hCYP1A1 together with hGSTP1 were 2-fold less sensitive to 5MC or 5MC-1,2-diol cytotoxicity than their CYP-only parent lines. 5mc-1,2-diol cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 The 5MC was highly mutagenic with similar potency in both hCYP-transfected cell lines, while 5MC-1,2-diol was 2-fold more mutagenic in hCYP1B1-transfected cells as compared to hCYP1A1 cells. 5mc-1,2-diol cytochrome P450 family 1 subfamily B member 1 Homo sapiens