Title : Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts.

Pub. Date : 2009 Feb

PMID : 18986645






3 Functional Relationships(s)
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1 RESULTS: The addition of nicotine and/or LPS to the culture medium increased the expression of MMP-1, -2, and -3 and tissue-type PA (tPA); decreased the expression of TIMP-1, -3, and -4; and did not affect expression of TIMP-2 or PAI-1. Nicotine matrix metallopeptidase 1 Homo sapiens
2 In the presence of NS398 or celecoxib, the stimulatory effects of nicotine and LPS on MMP-1 expression were unchanged, but they were unable to stimulate PGE(2) production. Nicotine matrix metallopeptidase 1 Homo sapiens
3 CONCLUSION: These results suggest that nicotine and LPS stimulate the resorption process that occurs during turnover of osteoid by increasing the production of MMPs and tPA and by decreasing the production of TIMPs. Nicotine matrix metallopeptidase 1 Homo sapiens