Title : The effects of chiral isolates of methadone on the cardiac potassium channel IKr.

Pub. Date : 2009

PMID : 18984955






2 Functional Relationships(s)
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1 At 0.1, 0.3 and 1 mM, s-methadone reduced HERG current by 50 +/- 4, 76 +/- 5 and 87 +/- 5%, respectively, while r-methadone reduced HERG current by 26 +/- 4, 53 +/- 3 and 77 +/- 3%, respectively. Methadone potassium voltage-gated channel subfamily H member 2 Homo sapiens
2 At 0.1, 0.3 and 1 mM, s-methadone reduced HERG current by 50 +/- 4, 76 +/- 5 and 87 +/- 5%, respectively, while r-methadone reduced HERG current by 26 +/- 4, 53 +/- 3 and 77 +/- 3%, respectively. Methadone potassium voltage-gated channel subfamily H member 2 Homo sapiens