Title : Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha.

Pub. Date : 2009 Jan 2

PMID : 18984580






1 Functional Relationships(s)
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Protein Name
Organism
1 Based on the high resolution crystal structure of human leukotriene C4 synthase, a model of mPGES-1 has been constructed in which the tripeptide co-substrate glutathione is bound in a horseshoe-shaped conformation with its thiol group positioned in close proximity to Arg-126. tripeptide K-26 leukotriene C4 synthase Homo sapiens