Title : Hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) or glyoxal (carbonylation model): prevention by bioactive nut extracts or catechins.

Pub. Date : 2009 Mar 16

PMID : 18983988






3 Functional Relationships(s)
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1 Hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) or glyoxal (carbonylation model): prevention by bioactive nut extracts or catechins. Glyoxal NUT midline carcinoma, family member 1 Rattus norvegicus
2 This study was conducted to evaluate the cytoprotectiveness of various nut extracts and bioactive compounds found in nuts for decreasing cytotoxicity, lipid peroxidation and protein carbonylation in cell toxicity models of diabetes-related carbonyl (glyoxal) and oxidative stress (hydroperoxide). Glyoxal NUT midline carcinoma, family member 1 Rattus norvegicus
3 Our results suggest (a) that bioactive nut constituents in the non-lipophilic extracts were more effective than lipophilic extracts for cytoprotection against hydroperoxide induced oxidative stress, (b) catechin compounds under physiological conditions were likely effective at preventing glyoxal cytotoxicity by trapping glyoxal or reversing early stage carbonylation (Schiff base formation). Glyoxal NUT midline carcinoma, family member 1 Rattus norvegicus