Pub. Date : 2009 Feb
PMID : 18981260
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the absence of vitamin D(3), PXR activates the CYP24A1 gene by directly binding to and transactivating vitamin D-response elements (VDREs) within its promoter. | Vitamin D | cytochrome P450, family 24, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Vitamin D(3) activates the CYP24A1 promoter by dissociating the corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) from the vitamin D receptor (VDR) on those VDREs. | Vitamin D | cytochrome P450, family 24, subfamily a, polypeptide 1 | Mus musculus |
| 3 | PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. | Vitamin D | cytochrome P450, family 24, subfamily a, polypeptide 1 | Mus musculus |
| 4 | PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. | Vitamin D | cytochrome P450, family 24, subfamily a, polypeptide 1 | Mus musculus |
| 5 | PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. | Vitamin D | cytochrome P450, family 24, subfamily a, polypeptide 1 | Mus musculus |
| 6 | PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. | Vitamin D | cytochrome P450, family 24, subfamily a, polypeptide 1 | Mus musculus |
| 7 | Thus, our present study defines the novel molecular mechanism by which PXR and CAR mediate drug interactions with vitamin D(3) to regulate the CYP24A1 gene. | Vitamin D | cytochrome P450, family 24, subfamily a, polypeptide 1 | Mus musculus |