Pub. Date : 2008 Nov 1
PMID : 18974122
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The phosphorylation of Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) is elevated in Cas-overexpressing cells treated with Adriamycin, whereas expression of the proapoptotic protein Bak is decreased. | Doxorubicin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Based on these data, we propose that Cas activates growth and survival pathways regulated by c-Src, Akt, and ERK1/2 that lead to the inhibition of mitochondrial-mediated apoptosis in the presence of Adriamycin. | Doxorubicin | mitogen-activated protein kinase 3 | Homo sapiens |