Title : Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes.

Pub. Date : 2009 Feb

PMID : 18973548






3 Functional Relationships(s)
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1 The effect of hydrogen peroxide on endothelial nitric oxide synthase expression in keratinocytes was examined using cultured keratinocytes. Hydrogen Peroxide nitric oxide synthase 3, endothelial cell Mus musculus
2 In vitro, stimulation with hydrogen peroxide decreased the expression level of endothelial nitric oxide synthase in cultured keratinocytes, which was restored by the addition of N-acetylcysteine. Hydrogen Peroxide nitric oxide synthase 3, endothelial cell Mus musculus
3 CONCLUSION: Reactive oxygen species, such as hydrogen peroxide, are responsible for the alveolar bone loss accompanied by decreased endothelial nitric oxide synthase expression in KK-A(y) mice. Hydrogen Peroxide nitric oxide synthase 3, endothelial cell Mus musculus