Title : Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies.

Pub. Date : 2009 Mar

PMID : 18964302






2 Functional Relationships(s)
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1 Using a bioassay involving Chinese hamster ovary cells transfected with the human thyrotropin receptor, we found that the stimulatory capacity of TRAbs was reduced markedly, by 66+/-22%, upon treatment with rituximab and methimazole for 21 days (p<0.0001), compared to an increase by 33% on average (NS) in patients receiving methimazole alone (p=0.04 between groups). Methimazole thyroid stimulating hormone receptor Homo sapiens
2 Using a bioassay involving Chinese hamster ovary cells transfected with the human thyrotropin receptor, we found that the stimulatory capacity of TRAbs was reduced markedly, by 66+/-22%, upon treatment with rituximab and methimazole for 21 days (p<0.0001), compared to an increase by 33% on average (NS) in patients receiving methimazole alone (p=0.04 between groups). Methimazole thyroid stimulating hormone receptor Homo sapiens