Pub. Date : 2009 Jan
PMID : 18927449
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. | Simvastatin | notch receptor 1 | Rattus norvegicus |
| 2 | We tested the hypothesis that simvastatin enhances arteriogenesis after stroke by increasing PS1 activation of the Notch signaling pathway. | Simvastatin | notch receptor 1 | Rattus norvegicus |
| 3 | RESULTS: Simvastatin significantly increased arterial diameter, density, and vascular smooth muscle cell proliferation, and upregulated PS1, Notch1, and NICD expression in the ischemic border tissue and in the cerebral arteries compared with MCAo control rats, respectively. | Simvastatin | notch receptor 1 | Rattus norvegicus |
| 4 | simvastatin treatment significantly increased arterial cell migration compared to control MCAo artery, whereas inhibition of Notch signaling activity by the gamma40-secretase inhibitor II significantly attenuated simvastatin-induced arterial cell migration. | Simvastatin | notch receptor 1 | Rattus norvegicus |