Title : Interleukin-1 stimulation of arachidonic acid release from human synovial fibroblasts; blockade by inhibitors of protein kinases and protein synthesis.

Pub. Date : 1991

PMID : 1892733






2 Functional Relationships(s)
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1 Protein kinase C activators PMA 4-phorbol 12-myristate 13-acetate and DiC8 (1,2-dioctanoyl-sn-glycerol) also increased arachidonic acid release, but the time course observed with PMA was different from that of IL-1. Tetradecanoylphorbol Acetate interleukin 1 alpha Homo sapiens
2 When cultures were treated with PMA for 16-24 h to down regulate protein kinase C, the ability of IL-1 to increase arachidonic acid release persisted to the same extent as in nontreated cultures. Tetradecanoylphorbol Acetate interleukin 1 alpha Homo sapiens