Pub. Date : 2008 Nov 11
PMID : 18922023
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The two published crystal structures of cytochrome P450 2C9, complexed with ( S)-warfarin or flurbiprofen, implicate a cluster of three active site phenylalanine residues (F100, F114, F476) in ligand binding. | Flurbiprofen | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | To elucidate the importance of CYP2C9"s active site phenylalanines on substrate binding, orientation, and catalytic turnover, a series of leucine and tryptophan mutants were constructed and their interactions with ( S)-warfarin and ( S)-flurbiprofen examined. | Flurbiprofen | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |