Title : 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription.

Pub. Date : 2008 Oct

PMID : 18852146






3 Functional Relationships(s)
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1 A mechanistic study showed the contributions of reactive oxygen species (ROS) and intracellular calcium in CHOP and DR5 gene up-regulation. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens
2 A mechanistic study showed the contributions of reactive oxygen species (ROS) and intracellular calcium in CHOP and DR5 gene up-regulation. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens
3 In summary, the effect of up-regulation of DR5 by 15dPGJ(2) in colon cancer cells is independent of PPAR-gamma and p53 but relies on CHOP induction through gene transcription involving ROS and calcium. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens