Pub. Date : 2008 Dec
PMID : 18850083
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Patch-clamp recording showed hyperpolarisation-activated currents in alpha-TC6 cells, which could be blocked by HCN channel inhibitor ZD7288. | ICI D2788 | cyclic nucleotide gated channel subunit alpha 1 | Rattus norvegicus |
| 2 | Calcium imaging studies showed that blockade of HCN channels by ZD7288 significantly increased intracellular calcium in alpha-TC6 cells, while lamotrigine or the Na(+) channel blocker tetrodotoxin suppressed the effect of ZD7288 on intracellular calcium. | ICI D2788 | cyclic nucleotide gated channel subunit alpha 1 | Rattus norvegicus |
| 3 | Calcium imaging studies showed that blockade of HCN channels by ZD7288 significantly increased intracellular calcium in alpha-TC6 cells, while lamotrigine or the Na(+) channel blocker tetrodotoxin suppressed the effect of ZD7288 on intracellular calcium. | ICI D2788 | cyclic nucleotide gated channel subunit alpha 1 | Rattus norvegicus |
| 4 | Furthermore, we found the HCN channel inhibitors ZD7288 and cilobradine both significantly increased glucagon secretion from rat islets. | ICI D2788 | cyclic nucleotide gated channel subunit alpha 1 | Rattus norvegicus |