Title : Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.

Pub. Date : 2009 Feb 8

PMID : 18842335






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Removal of the noviose moiety in novobiocin and introduction of a tosyl substituent at C-4 or C-7 coumarin nucleus provided derivatives 4TCNA and 7TCNA which compared favourably with novobiocin in MCF-7 breast cancer cells. coumarin complement C7 Homo sapiens