Pub. Date : 2008 Dec
PMID : 18836030
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thrombin increased the [Ca(2+)](cyt) in both cell types; however, the transient response was significantly higher and recovered quicker in the PASMC, suggesting different mechanisms may contribute to thrombin-mediated increases in [Ca(2+)](cyt) in these cell types. | pasmc | coagulation factor II, thrombin | Homo sapiens |
| 2 | Interestingly, CPA pretreatment significantly attenuated thrombin-induced Ca(2+) release in PASMC; this attenuation was not apparent in PAEC, indicating that a PAEC-specific mechanism was targeted by thrombin. | pasmc | coagulation factor II, thrombin | Homo sapiens |
| 3 | Notably, thrombin-induced receptor-mediated calcium influx was still observed in PASMC after CPA pretreatment in the presence of extracellular Ca(2+). | pasmc | coagulation factor II, thrombin | Homo sapiens |
| 4 | Ca(2+) oscillations were triggered by thrombin in PASMC resulting from a balance of extracellular Ca(2+) influx and Ca(2+) reuptake by the sarcoplasmic reticulum. | pasmc | coagulation factor II, thrombin | Homo sapiens |
| 5 | The data show that thrombin induces increases in intracellular calcium in PASMC and PAEC with a distinct CPA-, caffeine-, and ryanodine-insensitive release existing only in PAEC. | pasmc | coagulation factor II, thrombin | Homo sapiens |
| 6 | Furthermore, a dynamic balance between Ca(2+) influx, intracellular Ca(2+) release, and reuptake underlie the Ca(2+) transients evoked by thrombin in some PASMC. | pasmc | coagulation factor II, thrombin | Homo sapiens |