Title : Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors.

Pub. Date : 2009 Apr

PMID : 18830885






1 Functional Relationships(s)
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1 Preliminary structure-activity relationships and a molecular modeling study for 9a have revealed that the isoflavone moiety plays a key role in the interaction of this series of derivatives with AChE by acting as an anchor in its peripheral anionic site. Isoflavones acetylcholinesterase (Cartwright blood group) Homo sapiens