Title : Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.

Pub. Date : 2008 Oct 1

PMID : 18829547






1 Functional Relationships(s)
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1 Additionally, lapatinib significantly increased the accumulation of doxorubicin or mitoxantrone in ABCB1- or ABCG2-overexpressing cells and inhibited the transport of methotrexate and E(2)17betaG by ABCG2. Mitoxantrone ATP binding cassette subfamily B member 1 Homo sapiens