Title : Effects of manganese superoxide dismutase silencing on androgen receptor function and gene regulation: implications for castration-resistant prostate cancer.

Pub. Date : 2008 Oct 1

PMID : 18829485






2 Functional Relationships(s)
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1 The induction of many of these genes with SOD2 knockdown, such as VEGFA and FKBP5, is reversible with the antioxidant N-acetylcysteine, suggesting that this mechanism is directly linked to ROS. Acetylcysteine superoxide dismutase 2 Homo sapiens
2 SOD2 knockdown-induced AR activation was confirmed by electrophoretic mobility shift assay and luciferase activity, and both were readily reversible with N-acetylcysteine. Acetylcysteine superoxide dismutase 2 Homo sapiens