Title : 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.

Pub. Date : 2009 Jan

PMID : 18820127






1 Functional Relationships(s)
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1 The combination of SN-38 and 17AAG was shown to be synergistic in p53-null but not in parental HCT116 cells by median effect/combination index analysis. Irinotecan tumor protein p53 Homo sapiens