Pub. Date : 2009 Jan
PMID : 18820034
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Basolaterally applied SMase induced the phosphorylation of c-Jun NH(2)-terminal kinase (JNK), and inhibition of JNK rescued the effect of SMase on cAMP-dependant secretion. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Thus, conversion of sphingomyelin to ceramide in basolateral membranes of intestinal cells rapidly activates JNK to inhibit a cAMP-gated K(+) conductance and thereby attenuates Cl(-) secretion. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |