Pub. Date : 2008 Nov 25
PMID : 18814896
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. | Cholesterol | angiotensin converting enzyme 2 | Homo sapiens |
| 2 | We found that ACE2 of both Vero E6 and Caco-2 cells co-purifies with marker proteins of detergent-resistant membranes supporting the notion that cholesterol-rich microdomains provide a platform facilitating the efficient interaction of the S protein with the cellular receptor ACE2. | Cholesterol | angiotensin converting enzyme 2 | Homo sapiens |
| 3 | Depletion of cholesterol from the ACE2-expressing cells reduced the binding of S-expressing cells by 50% whereas the binding of soluble S protein was not affected. | Cholesterol | angiotensin converting enzyme 2 | Homo sapiens |