Title : Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells.

Pub. Date : 2008 Dec

PMID : 18809972






1 Functional Relationships(s)
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1 In contrast, eIF4E phosphorylation is low in PC3 and LNCaP cells with mutated PTEN and constitutively active AKT/mTOR pathway, but it can be strongly induced through inhibition of mTOR activity by rapamycin or serum depletion. Sirolimus eukaryotic translation initiation factor 4E Homo sapiens