Title : TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species.

Pub. Date : 2008 Sep 29

PMID : 18809716






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We demonstrate that Tsc1 deletion in the HSCs drives them from quiescence into rapid cycling, with increased mitochondrial biogenesis and elevated levels of reactive oxygen species (ROS). Reactive Oxygen Species TSC complex subunit 1 Homo sapiens
2 We demonstrate that Tsc1 deletion in the HSCs drives them from quiescence into rapid cycling, with increased mitochondrial biogenesis and elevated levels of reactive oxygen species (ROS). Reactive Oxygen Species TSC complex subunit 1 Homo sapiens