Title : Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target.

Pub. Date : 2008

PMID : 18804701






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The fluoroglutamic acids and fluoroglutamate-containing folates and antifolates exhibit position-dependent effects on the reactions catalyzed by FPGS and GH, thus providing insight into the catalytic mechanism and control of these enzymes. Folic Acid folylpolyglutamate synthase Homo sapiens