Pub. Date : 2008 Sep-Oct
PMID : 18804536
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Simvastatin inhibits cell cycle progression in glucose-stimulated proliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53. | Simvastatin | tumor protein p53 | Homo sapiens |
2 | We also found that simvastatin inhibited phosphorylation of Rb, promoted expression of p53, p16, p21, p27 and decreased CDK2/4 activity. | Simvastatin | tumor protein p53 | Homo sapiens |
3 | In conclusion, simvastatin inhibits VSMC proliferation in high glucose status, mimicking diabetes, inducing a G0/G1 phase cell cycle growth arrest by acting on multiple steps upstream of pRb, including inhibition of CDK2/4 expression and up-regulation of p53, p21, p16, and p27. | Simvastatin | tumor protein p53 | Homo sapiens |