Title : Docosahexaenoic acid downregulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the c-Jun NH2-terminal kinase mitogen-activated protein kinase pathway.

Pub. Date : 2009 Mar

PMID : 18803253






2 Functional Relationships(s)
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1 In the present study, we determined the effect of DHA on MAPK transactivation and its role in CYP 2B1 expression induced by phenobarbital. Phenobarbital mitogen activated protein kinase 3 Rattus norvegicus
2 c-Jun NH2-terminal kinase (JNK) JNK1/2 and ERK1/2 were activated by phenobarbital in a dose-dependent manner. Phenobarbital mitogen activated protein kinase 3 Rattus norvegicus