Title : Proline as a stress protectant in yeast: physiological functions, metabolic regulations, and biotechnological applications.

Pub. Date : 2008 Nov

PMID : 18802692






2 Functional Relationships(s)
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1 Based on the fact that proline has stress-protective activity, S. cerevisiae cells that accumulate proline were constructed by disrupting the PUT1 gene involved in the degradation pathway and by expressing the mutant PRO1 gene encoding the feedback inhibition-less sensitive gamma-glutamate kinase to enhance the biosynthetic activity. Proline glutamate 5-kinase Saccharomyces cerevisiae S288C
2 Based on the fact that proline has stress-protective activity, S. cerevisiae cells that accumulate proline were constructed by disrupting the PUT1 gene involved in the degradation pathway and by expressing the mutant PRO1 gene encoding the feedback inhibition-less sensitive gamma-glutamate kinase to enhance the biosynthetic activity. Proline glutamate 5-kinase Saccharomyces cerevisiae S288C