Title : AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver.

Pub. Date : 2008 Dec 5

PMID : 18801732






1 Functional Relationships(s)
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1 Reduced CREB phosphorylation (Ser-129) associated with inactivation of GSK3beta by Ser-9 phosphorylation may be the major mechanism underlying PEPCK-C gene suppression by AMPK-activating agents such as biguanide. Biguanides protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens