Pub. Date : 2008 Oct 28
PMID : 18801415
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Systemic administration of selective 5-HT1A agonists, such as 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OHDPAT), stimulates the electrical activity of ventral tegmental area (VTA) dopamine neurons by a mechanism which remains unknown. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 2 | Systemic administration of selective 5-HT1A agonists, such as 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OHDPAT), stimulates the electrical activity of ventral tegmental area (VTA) dopamine neurons by a mechanism which remains unknown. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 3 | administration of the 5-HT1A agonist 8-OHDPAT induced a strong stimulation of burst and firing activity of dopamine neurons. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 4 | Inactivation of the local 5-HT1A receptors by the microinfusion within the VTA of the selective 5-HT1A antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate (WAY 100,635), or of pertussis toxin, reduced the ability of 8-OHDPAT to stimulate the firing of dopamine neurons but not their burst activity. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 5 | On the other hand, burst activation elicited by 8-OHDPAT was strongly reduced following the inactivation of prefrontal 5-HT1A receptors achieved by the microinfusion of WAY 100,635 within the PFC. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |