Title : Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats.

Pub. Date : 2009 Jan 30

PMID : 18801389






2 Functional Relationships(s)
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1 Our results showed that intra-vlPAG injection of the endogenous agonist serotonin, the 5-HT1A/7 agonist 8-OH-DPAT or 5-HT2A/2C agonist DOI impaired the acquisition of inhibitory avoidance, without interfering with escape performance. Serotonin 5-hydroxytryptamine receptor 2A Rattus norvegicus
2 Moreover, as shown by the results of antagonism studies, 5-HT2A receptors are recruited for the anxiolysis caused by serotonin and DOI, while 5-HT1A receptors account for the effect of 8-OH-DPAT. Serotonin 5-hydroxytryptamine receptor 2A Rattus norvegicus