Title : Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.

Pub. Date : 2008 Oct 22

PMID : 18800802






1 Functional Relationships(s)
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1 TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin. Tetradecanoylphorbol Acetate thymoma viral proto-oncogene 1 Mus musculus