Title : Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1.

Pub. Date : 2008 Sep 15

PMID : 18794131






4 Functional Relationships(s)
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1 Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression. Curcumin mitogen-activated protein kinase 8 Homo sapiens
2 Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression. Curcumin mitogen-activated protein kinase 8 Homo sapiens
3 Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression. Curcumin mitogen-activated protein kinase 8 Homo sapiens
4 Our results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression. Curcumin mitogen-activated protein kinase 8 Homo sapiens