Pub. Date : 2008 Oct
PMID : 18792393
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alcohol feeding resulted in a significant increase in serum alanine aminotransferase levels, liver steatosis and triglyceride levels suggesting liver damage in WT, TLR2-KO, and MyD88-KO but not in TLR4-KO mice. | Alcohols | myeloid differentiation primary response gene 88 | Mus musculus |
| 2 | Expression of inflammatory mediators (tumor necrosis factor-alpha and interleukin-6) and TLR4 coreceptors (CD14 and MD2) was significantly higher in livers of alcohol-fed WT, TLR2-KO, or MyD88-KO, but not in TLR4-KO mice, compared to controls. | Alcohols | myeloid differentiation primary response gene 88 | Mus musculus |
| 3 | Alcohol feeding also induced nuclear factor-kappaB activation in a TLR4-dependent MyD88-independent manner. | Alcohols | myeloid differentiation primary response gene 88 | Mus musculus |