Pub. Date : 2008 Sep
PMID : 18790783
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this article, we present further evidence showing that elevated expression of dUTPase can protect breast cancer cells from the expansion of the intracellular uracil pool, translating to reduced growth inhibition following treatment with 5-FU. | Fluorouracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 2 | As 5-FU and the oral 5-FU prodrug capecitabine remain central agents in the treatment of a variety of malignancies, the clinical utility of a small-molecule inhibitor to dUTPase represents a viable strategy to improve the clinical efficacy of these mainstay chemotherapeutic agents. | Fluorouracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 3 | As 5-FU and the oral 5-FU prodrug capecitabine remain central agents in the treatment of a variety of malignancies, the clinical utility of a small-molecule inhibitor to dUTPase represents a viable strategy to improve the clinical efficacy of these mainstay chemotherapeutic agents. | Fluorouracil | Deoxyuridine triphosphatase | Drosophila melanogaster |