Title : Helioxanthin inhibits interleukin-1 beta-induced MIP-1 beta production by reduction of c-jun expression and binding of the c-jun/CREB1 complex to the AP-1/CRE site of the MIP-1 beta promoter in Huh7 cells.

Pub. Date : 2008 Oct 30

PMID : 18789903






2 Functional Relationships(s)
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1 To understand the mode of action of HE-145, we first examined how IL-1beta induced MIP-1beta expression at the molecular level. Helium C-C motif chemokine ligand 4 Homo sapiens
2 The reduction in IL-1beta-induced c-jun expression and subsequent binding of the c-jun/CREB1 complex to AP-1/CRE site mainly contributed to the inhibitory action of HE-145 on IL-1beta-induced MIP-1beta production. Helium C-C motif chemokine ligand 4 Homo sapiens