Title : Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.

Pub. Date : 2009 Jan 1

PMID : 18789002






2 Functional Relationships(s)
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1 Here we show that pyruvate is a specific inhibitor of HDAC1 and HDAC3. Pyruvic Acid histone deacetylase 3 Homo sapiens
2 These studies show that cancer cells effectively maintain low levels of pyruvate to prevent inhibition of HDAC1/HDAC3 and thereby to evade cell death. Pyruvic Acid histone deacetylase 3 Homo sapiens