Title : Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE).

Pub. Date : 2008 Nov

PMID : 18788085






1 Functional Relationships(s)
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1 Benzo[a]pyrene diol epoxide (B[a]PDE), the ultimate carcinogenic metabolite of benzo[a] pyrene, has been implicated in the mutagenesis of the p53 gene involved in smoking-associated lung cancer. Benzo(a)pyrene tumor protein p53 Homo sapiens