Title : Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.

Pub. Date : 2008 Nov 7

PMID : 18784074






1 Functional Relationships(s)
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1 Here we report that inhibition of cyclin-dependent kinases (Cdks) by kenpaullone and roscovitine (two small molecule inhibitors of Cdks that we identified in a screen for compounds that activate hPXR) leads to activation of hPXR-mediated CYP3A4 gene expression in HepG2 human liver carcinoma cells. kenpaullone cytochrome P450 family 3 subfamily A member 4 Homo sapiens