Title : Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state.

Pub. Date : 2008 Dec

PMID : 18779944






1 Functional Relationships(s)
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1 We observed that lovastatin blocked ras activation through inhibition of farnesylation and induced apoptosis, increasing ROS levels through inhibition of ERK1/2 signaling and Mn-SOD expression. Lovastatin mitogen activated protein kinase 3 Rattus norvegicus