Title : p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines.

Pub. Date : 2008 Nov

PMID : 18779317






1 Functional Relationships(s)
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1 Furthermore, the poly(I-C)-induced phosphorylation of IkappaB-alpha, nuclear translocation of NF-kappaB, and phosphorylation of interferon regulatory transcription factor 3, were drastically reduced in HCT116 p53(-/-) cells, indicating a dysregulation of the two signaling pathways governed by TLR3. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens