Pub. Date : 2008 Oct 14
PMID : 18778717
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells. | quinone | MYB proto-oncogene, transcription factor | Homo sapiens |
| 2 | BQ has been shown to increase the activity of c-Myb, which is an important transcription factor involved in hematopoiesis, cell proliferation, and cell differentiation. | quinone | MYB proto-oncogene, transcription factor | Homo sapiens |
| 3 | We hypothesized that BQ can increase c-Myb activity, which in turn increases Topo IIalpha promoter activity resulting in increased DNA strand breaks. | quinone | MYB proto-oncogene, transcription factor | Homo sapiens |
| 4 | However, BQ (37microM for 24h) exposure caused a significant increase in Topo IIalpha promoter activity, which could be blocked by the overexpression of the DBD polypeptide, suggesting that BQ exposure increases Topo IIalpha promoter activity through the c-Myb signaling pathway. | quinone | MYB proto-oncogene, transcription factor | Homo sapiens |
| 5 | However, BQ (37microM for 24h) exposure caused a significant increase in Topo IIalpha promoter activity, which could be blocked by the overexpression of the DBD polypeptide, suggesting that BQ exposure increases Topo IIalpha promoter activity through the c-Myb signaling pathway. | quinone | MYB proto-oncogene, transcription factor | Homo sapiens |