Pub. Date : 2008 Dec 15
PMID : 18772452
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. | Lenalidomide | keratin 20 | Homo sapiens |
| 2 | The anti-CD20 antibody rituximab is active in CLL and represents a rational agent to combine with lenalidomide. | Lenalidomide | keratin 20 | Homo sapiens |
| 3 | In contrast to previous reports using CD20-positive lymphoma cell lines, lenalidomide down-regulated CD20 surface antigen expression in CLL patient cells via enhanced internalization, without influencing transcription. | Lenalidomide | keratin 20 | Homo sapiens |
| 4 | In addition, CD20 surface antigen down-modulation by lenalidomide in CLL was accompanied by diminished rituximab-mediated apoptosis and ADCC. | Lenalidomide | keratin 20 | Homo sapiens |
| 5 | In addition, they suggest that lenalidomide therapy might be useful to enhance targeted delivery of RNAi-based therapies using CD20 immunoliposomes in B-cell malignancies. | Lenalidomide | keratin 20 | Homo sapiens |