Title : Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins.

Pub. Date : 2008 Nov

PMID : 18761711






2 Functional Relationships(s)
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1 Basal lactate uptake and release were significantly reduced by MCT1 knockdown, even more so than with basigin knockdown, whereas glutamate-driven or sodium azide-induced enhancement of lactate release was not inhibited by either MCT1, 2, or 4 small interfering RNAs. Lactic Acid solute carrier family 16 member 1 Homo sapiens
2 In conclusion, MCT1 plays a pivotal role in the control of basal proton-driven lactate flux in astrocytes while basigin is only partly involved, most likely via its interaction with MCT1. Lactic Acid solute carrier family 16 member 1 Homo sapiens